Yih-Lin Chung M.D.

Radiation Oncology
Medical Team: Colo-Rectal Cancer, Gynecological Cancer, Head and Neck & Nasopharyngeal Carcinoma, Urological Cancer, Soft Tissue Sarcoma & Melanoma, Neuro-Oncology

Current Title

  • Chief Attending, Department of Radiation Oncology, 2001-present

Specialties

  • Radiation oncology
  • Molecular biology

Clinical Interests

  • Radiation oncology
  • Molecular biology

Languages Spoken

  • Mandarin Chinese
  • Taiwanese
  • English

Education and Training

1984-1991 National Yang-Ming University, Taiwan, MD, Medicine
1991-1994 Residency, Surgery, Taipei Veterans General Hospital, Taiwan
1994-1997 University of Michigan-Ann Arbor, MI, USA, MS, PhD candidate, Human Genetics 
1995-1997 Research Assistant, Molecular Medicine Division of Internal Medicine, University of Michigan-Ann Arbor, MI, USA
1997-1999 Residency, Cancer Center, Taipei Veterans General Hospital, Taiwan
1999-2001 Fellowship, Radiation Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taiwan

Professional Experience

2001-present Attending Physician, Radiation Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taiwan

Professional Memberships

  • Taiwan Society of Radiological Technologists
  • Taiwan Society for Therapeutic Radiology and Oncology

Selected Publications

  1. Yen SH, Wang LW, Lin YH, Jen YM, Chung YL. PhenylbutyrateMouthwash Mitigates Oral Mucositis During Radiotherapy or Chemoradiotherapy in Patients with Head and Neck Cancer. Int J Radiat Oncol Biol Phys 82(4):1463-70, 2012.
  2. Chung YL, Pui NN. Phenylbutyratesuppresses distinct skin reactions that are enhanced by blockade of epidermal growth factor receptor signaling.J Dermatol Sci 64:163-173, 2011.
  3. Chung YL, and Tsai TY. Promyelocytic Leukemia Nuclear Bodies Link the DNA Damage Repair Pathway with Hepatitis B Virus Replication: Implications for Hepatitis B Virus Exacerbation during Chemotherapy and Radiotherapy. Mol Cancer Res 7(10):1672-1685, 2009.
  4. Chung YL, Lee MY, and Pui MN. Epigenetic therapy using the histone deacetylase inhibitor for increasing therapeutic gain in oral cancer: prevention of radiation-induced oral mucositis and inhibition of chemical-induced oral carcinogenesis. Carcinogenesis 30(8):1387-1397, 2009.
  5. Chung YL,Lee MY, Horng CF, Jian JJ, Cheng SH, Tsai SY, Hsieh CI, Yen LK, and Lin CY.Use of combined molecular biomarkers for prediction of clinical outcomes in locally advanced tonsillar cancers treated with chemoradiotherapy alone.Head Neck 31(1):9-20, 2009.
  6. Kuo LJ, Liu MC, Jian JJ, Horng CF, Cheng TI, Chen CM, Fang WT, Chung YL. Is final TNM staging a predictor for survival in locally advanced rectal cancer after preoperative chemoradiation therapy? Ann Surg Oncol 14(10):2766-2772, 2007.
  7. Chung YL, James Jer-Min Jian, Skye Hongiun Cheng, Stella Y.C. Tsai, Vincent P. Chuang, Thomas Soong, Yu-Mong Lin, Cheng-Fang Horng. Sublethal Irradiation Induces Vascular Endothelial Growth Factor and Promotes Growth of Hepatoma Cells: Implications for Radiotherapy of Hepatocellular Carcinoma. Clinical Cancer Research 12(9):2706-2715, 2006.
  8. Cheng SH, Tsai SY, Horng CF, Yen KL, Jian JJ, Chan KY, Lin CY, Terng SD, Tsou MH, Chu NM, Chen HH, Chen PL, Chung YL, Hsieh CI, Tan TD, Huang AT. A prognostic scoring system for locoregional control in nasopharyngeal carcinoma following conformal radiotherapy.Int J Radiat Oncol Biol Phys:66(4):992-1003, 2006.
  9. Chung YL, Jian JJ, Cheng SH, Hsieh CI, Tan TD, Chang HJ, Hung CF, Horng CF, Soong T, and Tsou MH. Extended-field radiotherapy and high-dose-rate brachytherapy with concurrent and adjuvant cisplatin-based chemotherapy for locally advanced cervical cancer: a phase I/II study. Gynecologic Oncology 97:126-135, 2005.
  10. Kuo LJ, Chern MC, Tsou MH, Liu MC, Jian JJ, Chen CM, Chung YL, Fang WT. Interpretation of magnetic resonance imaging for locally advanced rectal carcinoma after preoperative chemoradiation therapy.Dis Colon Rectum 48(1):23-28, 2005.
  11. Chung YL, Wang AJ, and Yao LF.Antitumor Histone Deacetylase Inhibitors Suppress Cutaneous Radiation Syndrome: Implications for Increasing Therapeutic Gain in Cancer Radiotherapy. Molecular Cancer Therapeutics 3(3):317-325, 2004.
  12. Chung YL, Lee MY, Wang AJ, and Yao LF. A Therapeutic Strategy Uses Histone Deacetylase Inhibitors to Modulate the Expression of Genes Involved in the Pathogenesis of Rheumatoid Arthritis.Molecular Therapy: The Official Journal of the American Society of Gene Therapy8(5):707-717, 2003.
  13. Chung YL, Sheu ML, and Yen SH. Hepatitis C Virus NS5A as a Potential Viral Bcl-2 Homologue Interacts with Bax and Inhibits Apoptosis in Hepatocellular Carcinoma. International Journal of Cancer107(1):65-73, 2003.
  14. Chung YL, Sheu ML, Yang SC, Lin CH, and Yen SH. Resistance to Tamoxifen-induced Apoptosis is Associated with Direct Interaction between Her2/neu and Cell Membrane Estrogen Receptor in Breast Cancer. International Journal of Cancer 97(3):306-312, 2002.
  15. Chung YL, Lee Wu YH, Yen SH, and Chi KW. A Novel Approach for Nasopharyngeal Carcinoma Treatment Uses Phenylbutyrate as a Protein Kinase C Modulator: Implications for Radiosensitization and Epstein-Barr Virus-Targeted Therapy. Clinical Cancer Research 6(4):1452-1458, 2000.
  16. Hu G, Chung YL, Glover T, Valentine V, Look AT, Fearon ER.Characterization of human homologs of the Drosophila seven in absentia (sina) gene. Genomics 46(1):103-111, 1997.

Patents  

Therapeutic Indication: CCRT side effects Patent Title Status
GI Mucositis, Dermatitis Method for increasing therapeutic gain in radiotherapy and chemotherapy (US2005-0272644) Issued in EU, China, Japan, Hong Kong; pending in USA
Oral Mucositis,
GI Distress, Cancer Fatigue Syndrome
Method and Compositions for Treatment of Epithelial Damage (US2006-0275370) Published, pending in USA
GI Distress Treatment of gastrointestinal distress (EP1719543; US20060229237) Issued in EU, China, Taiwan; pending in US, EU, Japan
Radiation Dermatitis Methods for therapy of radiation cutaneous syndrome (US6809118) Issued in USA, Taiwan
Radiation Fibrosis Treating radiation fibrosis (US6538030) Issued in USA
Wound Healing Histone hyperacetylating agents for promoting wound healing and preventing scar formation (US20070072793) Published, pending in USA

 

Therapeutic Indication: Quality of life Patent Title Status
Pruritus Method for ameliorating pruritus (US20080107646) Issued in EU, Canada, Australia, China, S. Korea, Japan, Taiwan; published & pending in USA
Rosacea Treatment skin disorders (US20110212161A1) Published and pending in USA, EU, Taiwan
Mucocutaneous and Ocular Toxicities in Targeted Therapy Method for treating or ameliorating mucocutaneous or ocular toxicities (US20120114745) Issued in Australia; published and pending in USA, EU, China, Taiwan, Korea and Japan
Joint Protection Prevention of joint destruction (US20050245439) Published in USA
Skin Care Reducing skin wrinkles and treating skin disorders (US8163764 B2) Issued in US; pending in Australia, EU and Taiwan
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