Skye Hung-Chun Cheng M.D.

Radiation Oncology
Medical Team: Breast Cancer, Thoracic Oncology, Colo-Rectal Cancer, Head and Neck & Nasopharyngeal Carcinoma, Lymphoma & Leukemia

Current Title

  • Chief, Department of Radiation Oncology, 2009-present

Specialties

  • Radiation oncology (breast cancer, head and neck cancer & nasopharyngeal cancer, colorectal cancer)

Clinical Interests

  • Radiation oncology (breast cancer, head and neck cancer & nasopharyngeal cancer, colorectal cancer)

Languages Spoken

  • Mandarin Chinese
  • English

Education and Training

1983 China Medical College, Taiwan, MD, Medicine
1985-1986 Residency, Internal  Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
1986-1990 Residency & Chief Resident (1989-1990), Radiation Oncology, Taipei Veterans General Hospital, Taiwan
1988-1990 Fellowship, Medical Oncology, Institute of Biomedical Sciences, Academia Sinica, Taiwan, under direction of Paul P. Carbone
1990-1991 Fellowship, Radiation Oncology, Taipei Veterans General Hospital, Taiwan
1992  Visiting Radiation Oncologist, Duke Unviersity Medical Center, Durham, NC, USA, under direction of Edward Halperin and Leonard Prosnitz
1993  Visiting Radiation Oncologist, Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA, under direction of CC Wang and Herman Suit

Professional Experience

2/2001-present Adjunct Associate Professor of Radiation Oncology, Duke University Medical Center, Durham, NC, USA
1/2002-present Committee Member, Commission on Hospital Accreditation of Department of Health, Taiwan
2/2008-present Clinical Professor of Radiation Medicine, National Yang-Ming University, Taiwan
3/2009-present Chief, Radiation Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taiwan

Professional Memberships

  • Member, Radiological Society of Republic of China, 7/1990-present
  • Member, Chinese Oncology Society in Taiwan, 11/1990-present
  • Member, American Society of Therapeutic Radiology and Oncology, 7/1999-present

Selected Publications

1991

  1. Zen (Cheng) SH, Jame JM, Chang AYC, Li WY, Law CK, Chen KY, Lin CZ. Nasopharyngeal carcinoma with bone marrow metastasis. American Journal of Clinical Oncology; 14: 66-70,1991. (SCI)
  2. Chang AYC, Su SWC, Zen (Cheng) SH, Wang WCC. Nasopharyngeal carcinoma in patients thirty years or younger. American Journal of Clinical Oncology; 14: 1-4,1991. (SCI)

1993

  1. Cheng SH, Jian JM, Chen CM, Huang AT. Breast-Preserving Therapy for Early Breast Cancer: A Preliminary Report and a Review of Literature. J. Chinese Oncol. Soc. 9: 8-21,1993.

1994

  1. Lin YM, Liu TW, Lin HH, Chen CM, Cheng SH, Huang AT, Sung JL. Endoscopic Features of Duodenal Metastases from Breast Cancer. Dig. Endosc. 6: 281-286,1994. (SCI)
  2. Kok V. CK, Huang AT, Lin HH, Cheng SH.  Metastatic Renal Cell Carcinoma with Protracted Course Masquerading Thyroid Carcinoma.  J. Chinese Oncol. Soc. 10:195-201,1994.

1995

  1. Cheng SH, Jian JM, Huang AT. Comments on Radiotherapy for Nasopharyngeal Carcinoma: Shielding the Pituitary May Improve Therapeutic Ratio. Int J Radiation Oncol Biol Phys 31:682-4, 1995. (SCI)
  2. Cheng SH, Kang SS, Chen CM, Huang PH, Chan JK, Jian JM. Dose Uniformity for the Triangle Between Tangential Fields and Internal Mammary Field in Breast Preservation Therapy.  Chinese J. Radiology 20: 53-62, 1995.
  3. Cheng SH, Chan WP, Lin YM, Liu MC, Chan KY, Jian JM. Magnetic Resonance Imaging in the Determination of Radiation Treatment Volume in Esophageal Carcinoma. J. Chinese Oncol. Soc. 11: 25-32, 1995. 
  4. Kok CK, Liu TW, Lin HH, Ou H, Cheng SH, Liu MC, Huang AT. Concomitant Renal Cell Carcinoma and Metastatic Epithelioid Angiosarcoma with Microangiopathy.  J Formos Med Assoc 94: 48-52,1995. (SCI)
  5. Kok VCK, Lin HH, Tso CY Liu TW, Chen MC, Liu MC, Jian J.M., Cheng SH: The Special Problem of Primary Lung Cancer in Young Patients Observed at A cancer Center.  J. of Chinese Oncology Society 11:8-15, 1995.
  6. 鄭鴻鈞﹐簡哲民:肢體保留:惡性軟組織肉瘤治療之新趨勢。台灣醫界38卷第7期33頁, 1995年。

1996

  1. Cheng SH, Chen CM, Jian JM, Tsai SYC, Liu TW, Liu MC, Chen MC, Lin HH.  Breast-Conserving Surgery and Radiotherapy for Early Breast Cancer.  J Formosa Med Assoc 95:372-7, 1996. (SCI)

 1997

  1. Cheng SH, Liu TW, Jian JM, Tsai SYC, Hao SP, Huang CH, Liu MC, Ben Yu, Huang AT. Concomitant Chemotherapy and Radiotherapy for Locally Advanced Nasopharyngeal Carcinoma.  Cancer J Sci Am 3(2): 100-106, 1997. (SCI)
  2. 鄭鴻鈞﹐陳啟明﹐于素英:「乳房保留治療術」後乳癌婦女對乳防滿意度之評估。台灣醫界40卷第1期第47頁, 1997年。
  3. 陳榮邦﹐鄭鴻鈞﹐詹光裕﹐劉美瑾:磁振造影對評估食道癌腫瘤範圍的前瞻性研究。台灣醫界40卷第2期10-12頁, 1997年。
  4. Cheng JC, Cheng SH, Tsai SYC, Jian JM, Huang AT. Concurrent Radiotherapy and Chemotherapy for Tonsillar Carcinoma. Chinese J Radiology 22: 193-197, 1997.
  5. Ch'ang HJ, Cheng SH, Liu MC, Jian JM, Chen CM.  Postoperative Concurrent Chemotherapy and Radiotherapy for Resectable Locally Advanced Gastric Cancer Patients. A Preliminary Report.  Therapeut Radiol Oncol 4: 195-201, 1997.

1998

  1. Jian JM, Cheng SH, Prosnitz LR, Tsai SYC, T’so CY, Huang AT. T Classification and Clivus Margin as Risk Factors for Determining Locoregional Control by Radiation of Nasopharyngeal Carcinoma. Cancer 82(2): 261-267, 1998. (SCI)
  2. Cheng SH, Jian JM, Tsai SYC, Chan KY, Yen LK, Chu NM, Tan TD, Tsou MH, Huang AT.  Prognostic Features and Treatment Outcome in Locoregionally Advanced Nasopharyngeal Carcinoma Following Concurrent Chemotherapy and Radiotherapy. Int J Radiation Oncol Biol Phys1998; 41(4): 755-762. (SCI)
  3. Cheng SH, Jian JM, Chan KY, Yu B, Tsai SYC, Liu MC, Chen CM,: The Benefit and Risk of Post-Mastectomy Radiation Therapy in High Risk Breast Cancer Patients. Am J Clin Oncol 21(1): 12-17, 1998. (SCI)
  4. Cheng JC, Cheng SH, Lin KJ, Jian JM, Chan KY, Huang AT.  Diagnostic Thoracic Computed Tomography in Radiotherapy for Locoregional Recurrent Breast Carcinoma. Int J Radiation Oncol Biol Phys; 41: 607-613,1998. (SCI)
  5. Ch'ang HJ, Jian JM, Cheng SH, Liu MC, Leu SY, Wang KY, Tsai SYC, Tsao MH, Lin HH, Huang AT. Sung JL.  Preoperative Concurrent Chemotherapy and Radiotherapy in Rectal Cancer Patients.  J. Formos Med Assoc. 97(1): 32-37,  1998. (SCI)
  6. Tsou MH, Tan TD, Cheng SH, Chiou YK.  Small Cell Carcinoma of the Uterine Cervix with Large Cell Neuroendocrine Carcinoma Component.  Gynecol Oncol 68(1): 69-72, 1998. (SCI)
  7. Cheng SH. Current Advances in Radiation Oncology. Formosa J Medicine 1998, 2: 1-5.

1999

  1. Cheng SH, Chen CM, Liu MC, Huang AT.Clinical Practice Guidelines for Breast Cancer.  J. Chinese Oncol. Soc 1999; 15:12-28.
  2. Cheng SH, Tsou MH, Chen CM, Leu SY, Huang AT.  Establishing A Comprehensive Breast Cancer Data Base In A New Free-Standing Cancer Center. J. Chinese Oncol. Soc 1999; 15: 29-40.
  3. Cheng JC, Wu JK, Huang JC, Cheng SH, Huang D, Jian JM, Yang PS.  Dose-volume analysis for 4 patients with radiation-induced liver disease after 3-dimentional conformal radiotherapy for hepatocellular carcinoma. Therapeut Radiol Oncol 1999; 6 (1): 55-61.
  4. Cheng SH, Lin YM, Chuang VP, Yang PS, Huang AT, Sung JL. A Pilot Study of Three-dimensional Conformal Radiotherapy in Unresectable Hepatocellular Carcinoma. J of Gastroenterology and Hepatology 1999; 14: 1025-33. (SCI) (Editorial comments by Y. Matsuzaki)
  5. Cheng JC, Cheng SH, Jian JM. Comments on combined transcatheter arterial chemoembolization and local radiotherapy of unresectable hepatocellular carcinoma. Int J Radiation Oncol Biol Phys 1999; 45(3): 828. (SCI)
  6. Cheng JC, Cheng SH, Jian JM, Yen LK, Chan KY, Hsieh CI.  Definitive radiotherapy with or without chemotherapy for resectable head and neck cancer. Therapeut Radiol Oncol 1999; 6 (1): 33-39.

2000

  1. Hsieh CI, Liu MC, Cheng SH, Liu TW, Chen CM, Chen MC, Tsou MH, Huang AT. Adjuvant Sequential Chemotherapy with Doxorubicin Plus Cyclophos-phamide, and Fluorouracial with Concurrent Radiotherapy in Resectable Advanced Breast Cancer.  Am J Clin Oncol 2000 Apr;23(2):122-7. (SCI)
  2. Cheng JC, Chuang VP, Cheng SH, Huang AT, Lin YM, Cheng TI, Yang PS, You DL, Jian JM, Tsai SY, Sung JL, Horng CF. Local radiotherapy with or without transcatheter arterial chemoembolization for patients with unresectable hepatocellular carcinoma. Int J Radiation Oncol Biol Phys 2000 May; 47 (2): 435-442. (SCI)
  3. Cheng SH,Tsai SYC, Yen LK, Jian JM, Chu NM, Chan KY, Tan TD, Cheng JC, Hsieh CY, Huang AT. Concomitant Radiotherapy And Chemotherapy for Early-Stage Nasopharyngeal Carcinoma. J Clinical Oncology 2000 May; 18(10): 2040-45. (SCI)
  4. Cheng SH, Tsou MH, Liu MC, Jian JM, Cheng JC, Leu SY, Huang AT.  Unique Features of Breast Cancer in Taiwan. Breast Cancer Research and Treatment 2000 October; 63 (3):213-223. (SCI)
  5. Cheng JC, Chen CM, Liu MC, Tsou MH, Yang PS, Cheng SH. Locoregional Recurrence of Post-Mastectomy Patients with 1-3 Positive Axillary Nodes Without Radiotherapy. J Formos Med Assoc. 2000 Oct; 99(10):759-65. (SCI)
  6. Chung YL, Cheng SH,Tsai SYC, Cheng JC, Jian JM. An effective, efficient and safe method to delivery a modified 3-D radiotherapy in locally advanced nasopharyngeal carcinoma. Therapeut Radiol Oncol 2000; 7: 137-145.
  7. Cheng SH,Jian JM, Tsai SYC, Yen KL, Chu NM, Chan KY, Tan TD, Cheng JC, Hsieh CY, Huang AT. Long-Term Survival of Nasopharyngeal Carcinoma Following Concomitant Radiotherapy And Chemotherapy. Int J Radiation Oncol Biol Phys 2000 Dec; 48(5): 1323-1330. (SCI) (Editorial comments by J.S. Cooper)

 2001

  1. Cheng SH,Yen KL, Jian JM, Tsai SYC, Chu NM, Leu SY, Chan KY, Tan TD, Cheng JC, Hsieh CY, Huang AT.  Examining Prognostic Factors and Patterns of Failure in Nasopharyngeal Carcinoma Following Concomitant Radiotherapy And Chemotherapy: Impact on Future Clinical Trials. Int J Radiation Oncol Biol Phys 2001; 50(3): 717-726. (SCI)
  2. Cheng JCH, Chuang VP, Cheng SH, Lin YM,Cheng TI, Yang PS, Jian JJM, You DL, Horng CF, Huang AT. Unresectable Hepatocellular Carcinoma Treated with Radiotherapy and/or Chemoembolization. Int J Cancer 2001; 96: 243-252. (SCI)

2002

  1. Cheng JC, Wu JK, Huang CM, Huang DY, Cheng SH, Lin YM, Jian JM, Yang PS, Chuang VP, Huang AT. Radiation-induced liver disease after radiotherapy for hepatocellular carcinoma: Clinical manifestation and dosimetric description. Raiotherapy and Oncology 2002; 63: 41-45. (SCI)
  2. Cheng SHand Yen KL. In response to Drs Cengiz, Özyar and Atahan. Int J Radiation Oncol Biol Phys 2002; 52 (4): 1144-1145. (SCI)
  3. Cheng JC, Chen CM, Liu MC, Tsou MH, Yang PS, Jian JM, Cheng SH, Tsai SYT, Leu SY, Huang AT. Locoregional failure of Post-Mastectomy Patients who had 1-3 Positive Axillary Nodes Without Radiotherapy. Int J Radiation Oncol Biol Phys; 2002; 52 (4): 980-988. (SCI)
  4. Jian JM, Cheng SH, Tsai SYC, Yen KL, Chu NM, Chan KY, Tan TD, Cheng JC, Lin YC, Leu SY, Hsieh CI, Tsou MH, Lin CY, Huang AT. Improvement of Local Control of T3 and T4 Nasopharyngeal Carcinoma By Hyperfractionated Radiotherapy and Concomitant Chemotherapy. Int J Radiation Oncol Biol Phys 2002; 53 (2):  344-352. (SCI)
  5. Cheng JC, Wu JK, Huang CM, Liu HS, Huang DY, Cheng SH, Tsai SY, Jian JJ, Lin YM, Cheng TI, Horng CF, Huang AT. Radiation-induced liver disease after three-dimensional conformal radiotherapy for patients with hepatocellular carcinoma: dosimetric analysis and implication. Int J Radiat Oncol Biol Phys. 2002 Sep 1;54(1):156-62. (SCI)
  6. Huang CM, Cheng JC, Tsai SY, Liu MC, Chung YL, Cheng SH, Fang WT, Yang PS, Jian JM, Huang AT. Rarely reported liver toxicity in patients who were hepatitis B carrier and underwent chemoirradiation for gastric cancer. Therapeutic Radiology and Oncology 2002, 9: 31-39.
  7. Cheng TI, Wong JM, Hung CF, Cheng SH, Cheng TJ, Shieh MJ, Lin YM, Tso CY, Huang AT, Colorectal Cancer Screening in Asymptomatic Adults: Comparison of Colonoscopy, Sigmoidoscopy and Fecal Occult Blood Tests. J Formosa Med Assoc 2002 Oct;101(10):685-90. (SCI)

2003

  1. Cheng JC, Wu JK, Huang CM, Liu HS, Huang DY, Tsai SY, Cheng SH, Jian JM, Huang AT, Dosimetric analysis and comparison of three-dimensional conformal radiotherapy and intensity-modulated radiation therapy for patients with hepatocellular carcinoma and radiation-induced liver disease. Int. J. Radiation Oncology Biol. Phys., 2003, 56: 229-234. (SCI)
  2. Huang E, Cheng SH, Dressman H, Pittman J, Tsou MH, Horng CF, Bild A, Iversen ES, Liao M, Chen CM, West M, Nevins JR, and Huang AT. Gene expression predictors of breast cancer outcomes. Lancet 2003, 361: 1590-96. (SCI)
  3. Kuo LJ, Leu SY, Liu MC, Jian JJ, Cheng SH, Chen CM. How aggressive should we be in patients with stage IV colorectal cancer? Dis Colon Rectum. 2003 Dec;46(12):1646-52. (SCI)  

2004

  1. Jong YJ, Li LH, Tsou MH, Chen YJ, Cheng SH, Wang-Wu SS, Tsai SF, Chen CM, Huang AT, Hsu MT, Lin CH. Chromosomal comparative genomic hybridization abnormalities in early- and late-onset human breast cancers: correlation with disease progression and TP53 mutationsCancer Genetics and Cytogenetics 148 (2004) 55–65. (SCI)
  2. Pittman J, Huang E, Dressman H., Horng CF, Cheng SH., Tsou MH., Chen, CM.,  Bild, A., Iversen, E., Huang, A., Nevins, J., and West, M. Integrated Modeling of Clinical and Gene Expression Information for Personalized Prediction  of Disease Outcomes. PNAS, 2004; 101: 8431-46. (SCI)
  3. 鄭鴻鈞, 美國癌症醫療品質監測的現況。  台灣醫界  2004;47(3):54-56.

2005

  1. Cheng SH,Tsai SYC, Yen KL, Jian JM, Feng AC, Chan KY, Hong CF, Chu NM, Lin YC, Lin CT, Tan TD, Hsieh CI, Chong V, Huang AT. Prognostic Significance of Parapharyngeal Space Venous Plexus and Marrow Involvement: Potential Landmarks of Dissemination for Stage I-III Nasopharyngeal Carcinoma. Int. J. Radiation Oncology Biol. Phys. 2005; 61(2): 456-465. (SCI)
  2. Cheng SH, Huang AT. Comments on concurrent chemotherapy and radiotherapy in nasopharyngeal carcinoma: A mist of mysterious result.J Clin Oncol 2005; 23:2864-5. (SCI)
  3. Chung YL, Jian JM, Cheng SH, Hsieh CI, Tan TD, Chang HJ, Hung CF, Horng CF, Soong T, Tsou MH. Extended-field radiotherapy and high-dose-rate brachytherapy with concurrent and adjuvant cisplatin-based chemotherapy for locally advanced cervical cancer: a phase I/II study. Gynecologic Oncology 2005; 97:126-135. (SCI)
  4. Tsai SYC, Cheng SH, Jian JJM, Huang CM, Yen KL, Chan KY, Leu SY, Lin YC, Chu NM, Tan TD, Hsieh CY, Tsou MH, Lin CY, Hung AT. Brain Stem Doses for patients of T3/T4 Nasopharyngeal Carcinoma Treated by Bid Irradiation and Concomitant Chemotherapy. Therapeut Radiol Oncol 2005; 12 (3):167-180.
  5. Lee MM, Chang IY, Horng CF, Chang JS, Cheng SH, Huang AT. Breast cancer and dietary factors in Taiwanese women. Cancer Causes Control 2005; 16(8): 929-37. (SCI)

2006

  1. Cheng SH; Horng CF; Pittman J; Tsou MH; Chen CM; Tsai SY; West M; Huang AT; Prosnitz LR.  Prognostic Index Score and Clinical Prediction Model of Local Regional Recurrence Following Mastectomy in Breast Cancer Patients. Int. J. Radiation Oncology Biol. Phys. 2006; 64(5): 1401-1409. (SCI)
  2. Feng AC, Wu MC, Tsai SYC, Chan KY, Cheng SH, Wang A, Jian JM, Chu NM, Hsieh CI, Yen KL, Terng SD, Tsou MH, Huang AT. Prevertebral muscle involvement in nasopharyngeal carcinoma. Int. J. Radiation Oncology Biol. Phys.2006; 65(4): 1026-1035. (SCI)
  3. Cheng SH;Horng CF; West M; Huang, E; Pittman J; Tsou MH; Dressman H; Chen CM; Nevins JR; Huang AT. Genomic Prediction of Loco-regional Recurrence Following Mastectomy in Breast Cancer. J Clinical Oncology 2006; Volume 24: 4594-4602. (SCI)
  4. Chung YL, Jian JJ, Cheng SH, Tsai SY, Chuang VP, Soong T, Lin YM, Horng CF. Sublethal irradiation induces vascular endothelial growth factor and promotes growth of hepatoma cells: implications for radiotherapy of hepatocellular carcinoma. Clin Cancer Res 2006; 12(9): 2706-15. (SCI)
  5. Cheng SH,Tsai SYC, Horng CF, Yen KL, Jian JM, Chan KY, Lin CY, Terng SD, Tsou MH, Chu NM, Chen HH, Chen PL, Chung YL, Hsieh CI, Tan TD, and Huang AT. A Prognostic Scoring System for Loco-regional Control in Nasopharyngeal Carcinoma Following Conformal Radiotherapy. Int. J. Radiation Oncology Biol. Phys.2006; 66(4): 992–1003. (SCI)
  6. Chung KP, Lai MS, Cheng SH, Tang ST, Huang CC, Cheng AL, Hsieh PC. Organization-based performance measures of cancer care quality: Core measure development for breast cancer in Taiwan. European Journal of Cancer Care 2006 (In revision). (SCI)
  7. Cheng SH, Wang CJ, Lin JL, Lu MC, Asch SM, Hilborne LH, Liu MC, Chen CM, and Huang AT. Optimal Quality of Care Improving Survival in Breast Cancer Patients. J Clinical Oncology (in revision)

 2007

  1. Cheng SH,Prosnitz LR. Utilizing Clinical and Genomic Information to Select Patients for Postmastectomy Radiotherapy. The American Journal of Hematology/Oncology 2007; 6(4), 213-216. (SCI)
  2. Huang KK, Lu MC, Tsou MH, Lin Christopher K.J., Cheng SH, Jian JM. Risk Factors for Ipisilateral Breast Tumor Recurrence in Patients with Ductal Carcinoma in Situ Undergoing Wide Excision Alone. Therapeutic Radiology and Oncology. 2007;14(3):141-147.
  3. Liu MC, Lu MC, Chen CM, Lin Christopher K.J., Tsou MH, Tsai SYC, Cheng SH, Jian JM. Prognostic Factors of Local-Regional Recurrence After Breast-Conserving Surgery And Radiation Therapy With/Without Chemotherapy for Early Breast Cancer. Therapeutic Radiology and Oncology. 2007; 14(3):148-151.

2008

  1. Chung KP, Lai MS, Cheng SH, Tang ST, Huang CC, Cheng AL, Hsieh PC. Organization-based performance measures of cancer care quality: Core measure development for breast cancer in Taiwan. European Journal of Cancer Care. European Journal of Cancer Care 2008; 17, 5–18.(SCI)
  2. Wu JS, Horng CF, Tsai SYC, Chung YL, Jian JM, Cheng SH. The Comparison Of Nodal Stage Determined By Magnetic Resonance Imaging And Clinical Palpation For Nasopharyngeal Carcinoma Patients With Bulky Lymph Node Metastasis. Therapeutic Radiology and Oncology. 2008 (reprint)
  3. Cheng SH,Jian JM, Tsai SYC, Horng CF, Chan KY, Lin JC, Lin CY, Terng SD, Tsou MH, Chu NM, Yen KL, Chen HH, Chi KH, Liu TW and Huang AT. New Prognostic Score to Predict Distant Metastasis in Nasopharyngeal Carcinoma Following Conformal Radiotherapy. Lancet Oncology (Submission)

2009

  1. Cheng SH, Wang CJ, Lin JL, Horng CF, Lu MC, Asch SM, Hilborne LH, Liu MC, Chen CM, and Huang AT. Optimal Quality of Care Improving Survival in Breast Cancer Patients. Medical Care 2009;47: 217–225.(SCI)
  2. Chung KP, Chang YJ, Cheng SH, et al. Is quality of colorectal cancer care good enough? Core measures development and its application for comparing hospitals in Taiwan. BMC Health Services Research 2010, 10:27.
  3. Wang AA, Chan KY, You DL, Feng AC, Cheng SH, Huang AT.The Significance of Tc-99 SPECT and MRI Findings in the Diagonosis of Skull base Invasion in Nasopharyngeal Carcinoma. Journal of Chinese Oncology Society 2009; 25(4), 241-253.
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